Escaping Local Optima in the Waddington Landscape: A Multi-Stage TRPO-PPO Approach for Single-Cell Perturbation Analysis
arXiv:2510.13018v1 Announce Type: new Abstract: Modeling cellular responses to genetic and chemical perturbations remains a central challenge in single-cell biology. Existing data-driven framework have advanced perturbation prediction through variational autoencoders, chemically conditioned autoencoders, and large-scale transformer pretraining. However, these models…
