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Predicting gene essentiality and drug response from perturbation screens in preclinical cancer models with LEAP: Layered Ensemble of Autoencoders and Predictors

arXiv:2502.15646v2 Announce Type: replace Abstract: High-throughput preclinical perturbation screens, where the effects of genetic, chemical, or environmental perturbations are systematically tested on disease models, hold significant promise for machine learning-enhanced drug discovery due to their scale and causal nature. Predictive…

Euclidean Distance Matrix Completion via Asymmetric Projected Gradient Descent

arXiv:2504.19530v2 Announce Type: replace Abstract: This paper proposes and analyzes a gradient-type algorithm based on Burer-Monteiro factorization, called the Asymmetric Projected Gradient Descent (APGD), for reconstructing the point set configuration from partial Euclidean distance measurements, known as the Euclidean Distance…

DeepRV: Accelerating spatiotemporal inference with pre-trained neural priors

arXiv:2503.21473v2 Announce Type: replace-cross Abstract: Gaussian Processes (GPs) provide a flexible and statistically principled foundation for modelling spatiotemporal phenomena, but their $O(N^3)$ scaling makes them intractable for large datasets. Approximate methods such as variational inference (VI), inducing points (sparse GPs),…