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Expanding functional protein sequence space using high entropy generative models

arXiv:2605.03578v1 Announce Type: cross Abstract: Boltzmann Machines trained on evolutionary sequence data have emerged as a powerful paradigm for the data-driven design of artificial proteins. However, the relationship between model architecture, specifically parameter density, and experimental performance remains poorly understood.…

DeRelayL: Sustainable Decentralized Relay Learning

arXiv:2605.02935v1 Announce Type: new Abstract: In the era of big data, large-scale machine learning models have revolutionized various fields, driving significant advancements. However, large-scale model training demands high financial and computational resources, which are only affordable by a few technological…

HiMAC: Hierarchical Macro-Micro Learning for Long-Horizon LLM Agents

arXiv:2603.00977v2 Announce Type: replace-cross Abstract: Large language model (LLM) agents have recently demonstrated strong capabilities in interactive decision-making, yet they remain fundamentally limited in long-horizon tasks that require structured planning and reliable execution. Existing approaches predominantly rely on flat autoregressive…

Proteo-R1: Reasoning Foundation Models for De Novo Protein Design

arXiv:2605.02937v1 Announce Type: new Abstract: Deep learning in emph{de novo} protein design has achieved atomic-level fidelity. However, existing models remain largely non-deliberative: they directly synthesize molecular geometries without explicitly reasoning about which residues or interactions are functionally essential. As a…